Year: 2018 | Month: August | Volume 8 | Issue 4
Deciphering the Functional Analysis of Bos taurus Insulin like Growth Factor 1 Receptor (IGF-1R) Protein through Insilico Approaches
Abstract:
The present study was conducted to know the detail functional aspects and molecular interaction of Insulin like growth factor 1 receptor (IGF-1R) of bos taurus at Department of Veterinary Biochemistry, College of Veterinary Science & AH, Bhubaneswar from time period between January 2018 to February 2018. IGF1R is one important tyrosine kinase receptor present on the cell surface of bovine as well as human plays a central role in differentiation of the cells and inhibition of apoptosis by mediating IGF1 signaling pathway. Thus, a functional analysis of this protein is required to know the various interactions with other proteins that will give a better platform for designing of drugs against different cancers in bovine. So in this study, the amino acid sequence of the bovine IGF-1R was retrieved from NCBI site, the retrieval of interacting proteins (STRING) platform was used to know the different protein networks for the functional analysis. The conserved domain was determined by using pfam database. It was found there were 11 nodes and 51 edges in its network and having strong interaction with Insulin preproprotein (INS) with score 0.993 but posses’ weak interaction with Phosphatidylinositol 3-kinase regulator protein with a score of 0.960. It was observed the Protein tyrosine kinase domain is conserved in this protein at the postion from 999 to1264, showing no co expression with other proteins in bos taurus.
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